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The Effect of Vitamin D Supplementation on HIV-associated Platelet Hyperreactivity

NCT02217553 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2014-08-18

No results posted yet for this study

Summary

Platelets play pivotal role in atherosclerosis and acute cardiovascular events. Platelet hyperreactivity and increase platelet-monocyte aggregate (PMA) formation are found in HIV infected patients, which may contribute to the excess cardiovascular risk. Low level of vitamin D has been associated with the presence of cardiovascular diseases. The aim of our study is to determine the effect of vitamin D supplementation on platelet activation, platelet reactivity and platelet-leukocyte complex formation in asymptomatic HIV-infected patients treated with ART

Conditions

  • Blood Platelet Disorders
  • Vitamin D Deficiency

Interventions

DRUG

Cholecalciferol

The study participants will receive 180 soft gel cholecalciferol capsules, to be taken 2 capsules once a day for 90 days

Sponsors & Collaborators

  • Radboud University Medical Center

    collaborator OTHER

  • Universitas Padjadjaran

    lead OTHER

Principal Investigators

  • Andre van der Ven, Professor · Radboud University Medical Center

  • Quirijn de Mast, Doctor · Radboud University Medical Center

  • Rudi Wisaksana, Doctor · Universitas Padjadjaran

  • Agnes R Indrati, Doctor · Universitas Padjadjaran

Study Design

Allocation
NA
Purpose
PREVENTION
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-12-31
Primary Completion
2014-02-28
Completion
2014-06-30

Countries

  • Indonesia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02217553 on ClinicalTrials.gov