Vitamin D Supplementation and Clinical Improvement in COVID-19

Summary

Background and objective Vitamin D is important as the interaction between vitamin D and its receptors at the immune cells stimulates innate and adaptive immunity. Deficiency in vitamin D is associated with increased susceptibility to infection and it is commonly found in Indonesia. Several studies indicate the potential of vitamin D supplementation against Coronavirus Disease 2019 (COVID-19), particularly in combating the proinflammatory situation as well as coagulopathy. This study aims to evaluate the supplementation of vitamin D in COVID 19 patients, particularly the changes in hematology parameters and other clinical parameters.

Method A double-blind randomized clinical trial is conducted among moderate COVID 19 patients. High-dose of vitamin D is given orally in the intervention group, compared with a low dose of vitamin D. Hematology parameters, D Dimer, conversion time on Polymerase Chain Reaction (PCR) test, and clinical symptoms are assessed

Hypothesis High Dose vitamin D shows a better hematology parameter, short PCR conversion time, and faster clinical recovery

Conditions

• COVID-19

Interventions

DIETARY_SUPPLEMENT

Vitamin D3 10000 IU

Tablet of 5000 IU of vitamin D3 given twice daily

DIETARY_SUPPLEMENT

Vitamin D3 1000 IU

Tablet of 1000 IU of vitamin D3 given once daily

Sponsors & Collaborators

• Bumi Herman

  lead OTHER

Principal Investigators

• Sisca Agustia, MD · Hasanuddin University

• Amirah Faisal, MD · Hasanuddin University

• Zahratul Fajri · Hasanuddin University

• Nurpudji Taslim, Prof · Hasanuddin University

• Suryani Armyn, Prof · Hasanuddin University

• Haerani Rasyid, Prof · Hasanuddin University

• Agussalim Bukhari, Prof · Hasanuddin University

• Irawaty Djaharuddin, Prof · Hasanuddin University

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2021-04-01

Primary Completion

2021-09-30

Completion

2021-11-01

Countries

• Indonesia

Study Locations