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The Effect of CRT on the Hypercapnic Ventilatory Response

NCT02203383 · Status: SUSPENDED · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2016-11-09

No results posted yet for this study

Summary

Central Sleep Apnoea (CSA) affects up to half of patients with severe heart failure and is associated with a poor prognosis. CSA is manifest as episodes of deep breathing interspersed with very shallow or absent breathing and is largely due to an exaggerated response to rising carbon dioxide in the blood, which normally drives how hard we breathe. Cardiac Resynchronization therapy (CRT), in which a pacemaker is implanted to improve co-ordinated contraction of the heart, has been shown to reduce the severity of CSA in some patient groups. We aim to determine whether this improvement is due to normalization of the body's response to carbon dioxide in the blood. Our hypothesis is that CRT improves CSA by normalizing the brain's response to carbon dioxide.

Conditions

Interventions

DEVICE

CRT Implantation

Implantation of a biventricular pacemaker or defibrillator.

Sponsors & Collaborators

  • Boston Scientific Corporation

    collaborator INDUSTRY

  • Royal Brompton & Harefield NHS Foundation Trust

    lead OTHER

Principal Investigators

  • Ali Vazir, PhD · Imperial College. Royal Brompton Hospital

  • Martin Cowie, MD · Imperial College London

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-06-30
Primary Completion
2017-10-31
Completion
2017-10-31

Countries

  • United Kingdom

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02203383 on ClinicalTrials.gov