Reducing Suicidal Ideation Through Treatment of Nightmares-Post Traumatic Stress Disorder (PTSD)
NCT02199652 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 20
Last updated 2018-09-18
Summary
Patients with PTSD, and frequent nightmares, and mild-moderate suicidal ideation, who are already taking a Selective Serotonin Reuptake Inhibitor (SSRI) or Serotonin Norepinephrine Reuptake Inhibitor (SNRI) will be randomized to either prazosin or placebo. The investigators hypothesize that patients receiving prazosin will have a greater reduction in suicidal ideation.
Conditions
- Post Traumatic Stress Disorder
- Suicidal Ideation
- Nightmares
Interventions
- DRUG
-
Prazosin
- DRUG
Sponsors & Collaborators
-
Augusta University
lead OTHER
Principal Investigators
-
William V McCall, MD, MS · Augusta University
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- SINGLE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Max Age
- 65 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2014-03-31
- Primary Completion
- 2017-09-01
- Completion
- 2017-12-01
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
Efficacy of Sleep Interventions for Posttraumatic Stress Disorder (PTSD)
NCT00393874 ·Status: COMPLETED ·Phase: NA
-
Prazosin vs Paroxetine in Combat Stress-Related Post-Traumatic Stress Disorder (PTSD) Nightmares & Sleep Disturbance
NCT00202449 ·Status: TERMINATED ·Phase: NA
-
Prazosin vs. Paroxetine in Combat Stress Symptoms in OIF/OEF Returnees
NCT00261729 ·Status: COMPLETED ·Phase: NA
-
Administration of Prazosin to Prevent PTSD in Adult Women After Sexual Assault
NCT03997864 ·Status: WITHDRAWN ·Phase: PHASE4
-
Feasibility Study: The Effect of Prazosin for Nighttime Symptoms of Civilian PTSD
NCT00174551 ·Status: UNKNOWN ·Phase: NA
-
Prazosin for Treatment of Patients With Alcohol Dependence (AD) and Post Traumatic Stress Disorder (PTSD).
NCT00744055 ·Status: COMPLETED ·Phase: PHASE3
-
Reducing Cannabis Overuse With Prazosin
NCT04721353 ·Status: COMPLETED ·Phase: PHASE4
-
Effect of Prazosin on Neurophysiology and Cognition in Post-Traumatic Stress Disorder (PTSD)
NCT00890643 ·Status: WITHDRAWN ·Phase: NA
-
Neurobiology of Sleep and Sleep Treatment Response in Returning Veterans
NCT01637584 ·Status: COMPLETED ·Phase: NA
-
An Open Label Pilot Study of IV Brexanolone for the Treatment of Post-Traumatic Stress Disorder
NCT05254405 ·Status: TERMINATED ·Phase: PHASE4
-
Effect of Propranolol on Preventing Posttraumatic Stress Disorder
NCT00158262 ·Status: COMPLETED ·Phase: PHASE4
-
Improving Treatment Outcomes for Suicidal Veterans With PTSD
NCT04690582 ·Status: COMPLETED ·Phase: NA
-
Treating Insomnia & Nightmares After Trauma: Impact on Symptoms & Quality of Life
NCT01009112 ·Status: COMPLETED ·Phase: NA
-
Prazosin Augmentation of Outpatient Treatment of Alcohol Use Disorders in Active Duty Soldiers With and Without PTSD
NCT02226367 ·Status: COMPLETED ·Phase: NA
-
Psychiatric Inpatient Nightmare Treatment
NCT04198142 ·Status: UNKNOWN ·Phase: NA
-
Enhancing the Effectiveness of Prolonged Exposure Among Suicidal Individuals With PTSD
NCT06285708 ·Status: RECRUITING ·Phase: NA
-
Cortisol Suppression and Startle Responses in Posttraumatic Stress Disorder (PTSD)
NCT01477762 ·Status: COMPLETED ·Phase: NA
-
Sleep-directed Hypnosis As A Complement To Cognitive Processing Therapy (CPT) In Treating Posttraumatic Stress Disorder (PTSD)
NCT00725192 ·Status: UNKNOWN ·Phase: NA
-
Pilot Study of PRX-03140 to Assess Safety for Use in Adult Subjects With Post Traumatic Stress Disorder
NCT01492699 ·Status: COMPLETED ·Phase: NA
-
Propranolol Reactivation Mismatch (PRM) Treatment for PTSD
NCT03652922 ·Status: UNKNOWN ·Phase: PHASE4
-
Topiramate in the Treatment of Post Traumatic Stress Disorder (PTSD)
NCT00203463 ·Status: COMPLETED ·Phase: PHASE4
-
Efficacy of a Brief Nightmare Treatment for Veterans
NCT01220401 ·Status: COMPLETED ·Phase: NA
-
Eszopiclone for Sleep Disturbance and Nightmares in Post-Traumatic Stress Disorder
NCT00120250 ·Status: COMPLETED ·Phase: PHASE4
-
Reducing Reconsolidation of Trauma Memories With Propranolol
NCT01349439 ·Status: UNKNOWN ·Phase: PHASE2
-
Stress Reactivity in Veterans Receiving Pharmacological Treatment for PTSD and Alcohol Dependence
NCT00923923 ·Status: COMPLETED ·Phase: NA