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Anesthetic Agents and Acute Kidney Injury After Liver Resection Surgery

NCT02174575 · Status: WITHDRAWN · Phase: PHASE4 · Type: INTERVENTIONAL

Last updated 2023-05-03

No results posted yet for this study

Summary

* It has been shown that patients who undergo liver resection surgery are at high risk for postoperative acute kidney injury (AKI).
* Sevoflurane may increase the risk for postoperative AKI because of production of compound-A.
* Therefore, we have planned to investigate the effects of different anesthetic agents on postoperative renal function.
* Patients undergoing liver resection surgery are randomized into 2 groups.
* One of the groups receives sevoflurane and the other group receives desflurane.
* Blood and urine specimen are sampled both pre- and postoperatively, and several biomarkers are compared between the groups.

Conditions

Interventions

DRUG

Sevoflurane

Sevoflurane is administered during anesthesia in Sevoflurane group.

DRUG

Desflurane

Desflurane is administered during anesthesia in Desflurane group.

Sponsors & Collaborators

  • Tokyo Medical and Dental University

    lead OTHER

Principal Investigators

  • Koshi Makita, M.D. · Tokyo Medical and Dental University

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-07-31
Primary Completion
2023-05-31
Completion
2023-05-31

Countries

  • Japan

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02174575 on ClinicalTrials.gov