Analysis of Telmisartan Administered With Antiretroviral Therapy (ART) in Patients With Acute HIV Infection

Summary

This research project will study whether the drug telmisartan administered in conjunction with antiretroviral therapy (ART) will help reduce nervous system infection with HIV. The investigators are studying the effect of this treatment in people who have contracted HIV infection within the past three weeks, and thus have a form of HIV called acute HIV infection. The investigators will measure biological markers of immune activation in the blood and cerebrospinal fluid to see if telmisartan may reduce the spread of HIV reservoirs in affected patients.

Conditions

• Acute HIV Infection
• HIV Infections

Interventions

DRUG

Telmisartan

Sponsors & Collaborators

• National Institute of Neurological Disorders and Stroke (NINDS)

  collaborator NIH

• SEARCH Research Foundation

  collaborator OTHER

• University of California, San Francisco

  collaborator OTHER

• Walter Reed Army Institute of Research (WRAIR)

  collaborator FED

• University of Hawaii

  collaborator OTHER

• National Institute of Mental Health (NIMH)

  collaborator NIH

• Yale University

  lead OTHER

Principal Investigators

• Serena Spudich, MD, MA · Yale University

• Jintanat Ananworanich, MD, PhD · U.S. Military HIV Research Program, Bethesda, Maryland

• Nittaya Phanuphak, MD, PhD · Thai Red Cross AIDS Research Centre, Bangkok, Thailand

Study Design

Allocation

RANDOMIZED

Purpose

OTHER

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2015-01-28

Primary Completion

2018-06-13

Completion

2018-06-13

Countries

• Thailand

Study Locations