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Establish and Characterize an Acute HIV Infection Cohort in a High Risk Population

NCT00796146 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 777

Last updated 2026-04-27

No results posted yet for this study

Summary

To describe clinical, immunological, and virological characteristics of persons with acute HIV infection

1. To describe demographics and behavioral risk factors for those identified with acute HIV infection
2. To describe neurocognitive function and neuroimaging findings in acute HIV infection as well as describe immune response, HIV-1 genotypes and sequences in the cerebrospinal fluid.
3. To describe the number and characteristics of sexual contacts
4. To describe the willingness of acute HIV-infected subjects to allow the tracking of their sexual contacts for voluntary HIV counseling and testing (VCT)
5. To describe immune response, HIV-1 genotypes and sequences in the genital compartment
6. To describe T cell depletion in the gut mucosa in acute HIV infection and describe the changes in gut T cell during follow up
7. To archive samples for future investigations including determination of viral evolution, and cell-mediated and humoral immune responses in peripheral blood and mucosal compartments

Conditions

  • Acute HIV Infection

Sponsors & Collaborators

  • Armed Forces Research Institute of Medical Sciences, Thailand

    collaborator OTHER_GOV

  • Thai Red Cross AIDS Research Centre

    collaborator OTHER

  • Yale University

    collaborator OTHER

  • National Institute of Allergy and Infectious Diseases (NIAID)

    collaborator NIH

  • University of California, San Francisco

    collaborator OTHER

  • National Institutes of Health (NIH)

    collaborator NIH

  • Johns Hopkins University

    collaborator OTHER

  • University of Missouri-Columbia

    collaborator OTHER

  • SEARCH Research Foundation

    lead OTHER

Principal Investigators

  • Sandhya Vasan, MD · US Military HIV Research Program

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2009-04-30
Primary Completion
2033-07-31
Completion
2033-07-31

Countries

  • Thailand

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00796146 on ClinicalTrials.gov