Impact of NAVA (Neurally Adjusted Ventilatory Assist) on Ventilatory Demand During Pediatric Non-Invasive Ventilation

Summary

Mechanical ventilation permits to support the work of breathing in case of respiratory failure, but therapy also has many side effects. Non-invasive ventilation (NIV), which delivers the ventilatory assist via a face mask or nasal canula, permits to decrease these complications. However, NIV is not always successful and half of children in respiratory failure finally require invasive ventilation. A major cause of NIV failure is the ventilator inability to detect patient efforts. The new ventilatory mode NAVA (neurally adjusted ventilatory assist) improves the detection of patient efforts during mechanical ventilation. The hypothesis of this study is that NAVA improves synchrony during pediatric NIV and therefore permits to unload the patient ventilatory efforts.

Conditions

• Respiratory Failure

Interventions

DEVICE

Neurovent Monitor XIII

Nasogastric tiube installation to monitor EAdi

DEVICE

Neurovent Monitor XIII

RIP jacket installation

DEVICE

Neurovent Monitor XIII

Ventilator change (if a different ventilator was used prior to the study).

DEVICE

Neurovent Monitor XIII

Determination of NAVA parametersVentilator

DEVICE

Neurovent Monitor XIII

Second period with conventional NIV settings

Sponsors & Collaborators

• St. Justine's Hospital

  lead OTHER

Principal Investigators

• Philippe A Jouvet, MD, PhD · St. Justine's Hospital

• Sylvain Morneau · St. Justine's Hospital

• Jennifer Beck, PhD · Li Ka Shing Knowledge Institute. St. Michael's Hospital

Study Design

Allocation

NA

Purpose

SUPPORTIVE_CARE

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

3 Days

Max Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2011-11-30

Primary Completion

2013-05-31

Completion

2013-05-31

Countries

• Canada

Study Locations