Does Sugared or Sugar Free Chewing Gum Reduces Postoperative Ileus After Laparoscopic Cholecystectomy

Summary

Laparoscopic cholecystectomy is now very common procedure to remove the gall bladder from abdomen. After this procedure many patients suffer from the non functioning of intestine and stomach which is very common after any abdominal surgery. Many efforts tried to reduce this non functioning period or postoperative ileus but non of them was superior later on. The investigators want to evaluate the role of chewing gum for reducing postoperative ileus. The investigators hypothesis is that Chewing gum after laparoscopic cholecystectomy reduces postoperative ileus and sugared preparations are more effective to reduce it.

Conditions

• Postoperative Ileus.

Interventions

OTHER

sugar free chewing gum

Sugar free chewing gum (orbit) was given to patients. They were asked to chew it 4 hours after surgery and continue to chew it 8 hourly for 20 to 25 min each time until oral feeding was started.

OTHER

sugared chewing gum

Sugared chewing gum (singsong bubble gum) was given to patients. They were asked to chew it 4 hours after surgery and continue to chew it 8 hourly for 20 to 25 min each time until oral feeding was started.

DRUG

Tab. Midazolam 7.5 mg

Tab. Midazolam 7.5 mg will be given to all patients at night before surgery.

DRUG

Inj. Midazolam 0.7mg/kg 45 min before surgery

Inj . Midazolam 0.7 mg/kg given as premedication.

DRUG

Inj. Propofol 2.5mg/kg

It was given to induce anesthesia after 3 min of pre oxygenation.

DRUG

Inj. Atracurium 0.5 mg/kg

It was given to induce muscle relaxation during anesthesia.

DRUG

Sevoflurane 2.5 vol %

It was given to maintain anesthesia during surgery alongwith oxygen in air mixture

DRUG

Inj. Cefuroxime 1.5 g IV

It was given as prophylactic antibiotic. 2 doses given. 1st 30-60 min before surgery. 2nd 6 hours after surgery

DRUG

Inj. Ketorolac 30 mg IV

3 doses for analgesia. 1st immediate postoperative, 2nd at 8 hours postoperative and 3 rd at 16 hours postoperative period.

DRUG

Inj. Zantac 50mg IV

2 doses. 1st at immediate postoperative and 2nd 12 hours after surgery

Sponsors & Collaborators

• Benazir Bhutto Hospital, Rawalpindi

  lead OTHER_GOV

Principal Investigators

• Fazal Hussain Shah, FCPS-I · Benazir Bhutto Hospital, Rawalpindi

• Aurangzeb khan, FCPS · Benazir Bhutto Hospital, Rawalpindi

• Muhammad Bilal Habshi, FCPS-I · Benazir Bhutto Hospital, Rawalpindi

• Arslan Zahid, FCPS-I · Benazir Bhutto Hospital, Rawalpindi

• Muhammad Zubair Saeed, FCPS-I · Benazir Bhutto Hospital, Rawalpindi

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

25 Years

Max Age

55 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2013-01-31

Primary Completion

2014-02-28

Completion

2014-02-28

Countries

• Pakistan

Study Locations