Treatment of Postoperative Nausea-Vomiting in Laparoscopic Cholecystectomy: Peppermint-Flavored Gum Versus Gum-Free

Summary

Postoperative nausea and vomiting (PONV) is an unwanted and distressing complication for patients. PONV affects one-third of untreated patients after general anesthesia. PONV is a hard state for patients, surgeons, and anesthesiologists and increases the anxiety of patient. There are many pharmacologic agents efficient in treatment and prophylaxis of PONV, however, these drugs have many side effects. At the same time, there are many non-pharmacological strategies for antiemetic therapies. Therefore there is an interest to nonpharmacologic agents. Such as acupuncture, ginger, peppermint …etc. Mint is a popular vegetable used as an antispasmodic, analgesic, antimicrobial and anti-vomiting treatment. The use of mint is safe and no certain side-effects and interactions. Chewing affects on postoperative bowel functions. Our hypothesis was mint chewing gum is effective on treatment of PONV. Laparoscopic cholecystectomy surgery has a high risk for PONV in adults. In this study, our aim is to investigate the effect of mint gum chewing in the treatment of PONV in laparoscopic cholecystectomy surgery.

Conditions

• Postoperative Nausea and Vomiting
• Chewing Gum

Interventions

DIAGNOSTIC_TEST

Abramowitz Emesis Score

Postoperative vomiting was evaluated by Abramowitz emesis score in recovery room.

DIAGNOSTIC_TEST

Degree of nausea

Degree of postoperative nausea was evaluated.

DIAGNOSTIC_TEST

Observer's Assessment of Alertness/Sedation Scale

Patients' sufficient wakefulness was evaluated by Observer's Assessment of Alertness/Sedation scale in the recovery unit.

DIAGNOSTIC_TEST

Patient Satisfaction

Patient satisfaction was questioned. Answers were recorded as one of the choices (never, sometimes, usually or always)

DIAGNOSTIC_TEST

Surgeon Satisfaction

Surgeon satisfaction was questioned. Answers were recorded as one of the choices (never, sometimes, usually or always)

OTHER

Chewing Peppermint gum

Peppermint gum was chewed for 15 minutes in patients with sufficient wakefullness.

Sponsors & Collaborators

• Bursa Yuksek Ihtisas Training and Research Hospital

  lead OTHER_GOV

Principal Investigators

• Canan Yılmaz · Medical Doctor of Anesthesiology Department

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

FACTORIAL

Eligibility

Min Age

18 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-05-01

Primary Completion

2018-05-01

Completion

2018-05-03

Countries

• Turkey (Türkiye)

Study Locations