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Exercise and Markers of Medial Temporal Health in Youth At-risk for Psychosis

NCT02155699 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2024-04-02

Study results available
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Summary

The goal of this proposal is to test the feasibility and effectiveness of cardiovascular exercise in promoting brain health and improving related symptoms (e.g., hearing sounds that are not there, feeling emotionally detached from self and others), cognitive difficulties (troubles with memory and learning), and every day social-occupational functioning in youth at imminent risk for developing a psychotic disorder such as schizophrenia. Understanding how exercise may protect or improve the health of a brain area that is implicated as a major contributing factor to the onset of psychosis may lead to a path-breaking new intervention that does not suffer from many of the side effects, costs, and other barriers that characterize treatments that are currently available for this group. Because a significant portion of high-risk youth go on to develop a psychotic disorder in a short period, intervening at this stage may help to improve the clinical course and ultimately prevent the onset of a devastating and prevalent mental illness.

Conditions

  • Attenuated Psychosis Syndrome

Interventions

BEHAVIORAL

Exercise 1

65% of VO2max and 2 sessions per week

BEHAVIORAL

Exercise 2

85% intensity and 3 sessions per peek

Sponsors & Collaborators

  • University of Colorado, Denver

    collaborator OTHER

  • National Institute of Mental Health (NIMH)

    collaborator NIH

  • Northwestern University

    collaborator OTHER

  • University of Colorado, Boulder

    lead OTHER

Principal Investigators

  • Vijay A Mittal, Ph.D. · University of Colorado, Boulder

  • Angela Bryan, Ph.D. · University of Colorado, Boulder

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
SINGLE_GROUP

Eligibility

Min Age
16 Years
Max Age
24 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-07-31
Primary Completion
2022-07-31
Completion
2022-07-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02155699 on ClinicalTrials.gov