A Study In Healthy People To Evaluate Safety, Toleration, Pharmacokinetics And Pharmacodynamics Of Multiple Oral Doses Of PF-06743649
NCT02151617 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 40
Last updated 2015-01-19
Summary
The purpose of this study in healthy people is to evaluate safety, toleration and time course of plasma concentration of multiple oral doses of PF-06743649. The pharmacodynamic activity of PF-06743649 will also be assessed. The effect of food on PK of PF-06743649 will also be investigated.
Conditions
- Healthy
Interventions
- DRUG
-
PF-06743649
40 mg tablet one time once with a meal and once without a meal, followed by once daily dosing for 14 days
- DRUG
-
Placebo tablet one time once with a meal and once without a meal, followed by once daily dosing for 14 days
- DRUG
-
PF-06743649
To be decided dose, tablet once daily dosing for 14 days
- DRUG
-
Placebo tablet once daily dosing for 14 days
- DRUG
-
PF-06743649
To be decided dose, tablet, one time once with a meal and once without a meal, followed by once daily dosing for 14 days
- DRUG
-
Placebo tablet one time once with a meal and once without a meal, followed by once daily dosing for 14 days
- DRUG
-
PF-06743649
To be decided dose, tablet, one time without a meal, followed by once daily dosing for 14 days
- DRUG
-
Placebo tablet one time once without a meal, followed by once daily dosing for 14 days
- DRUG
-
PF-06743649
Tablet, to be decided dose, once daily, 14 days
- DRUG
-
Tablet, once daily, 14 days
Sponsors & Collaborators
- lead INDUSTRY
Principal Investigators
-
Pfizer CT.gov Call Center · Pfizer
Study Design
- Allocation
- RANDOMIZED
- Purpose
- BASIC_SCIENCE
- Masking
- DOUBLE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Max Age
- 55 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2014-06-30
- Primary Completion
- 2014-12-31
- Completion
- 2014-12-31
Countries
- United States
Study Locations
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