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Study of Homing of Labelled Stem Cells in Human Heart.

NCT02148666 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 10

Last updated 2014-06-09

No results posted yet for this study

Summary

One of the challenges of stem cell therapy is to understand the fate of the injected stem cell. By labelling various stem cells with radioisotopes their fate (homing) can be demonstrated. In this study, we will develop and refine the existing techniques of stem cell labelling to various subtypes of stem cells namely- freshly aspirated bone marrow cells, cryopreserved bone marrow cells, g-csf mobilized peripheral blood stem cells and umbilical cord cells. After testing the labelling efficacy and viability, these cells will be injected in to the coronary arteries of patients with myocardial infarction who have undergone a successful revascularization either by angioplasty or thrombolysis. Homing of stem cells will be demonstrated by nuclear scan after the procedure. We are adapting techniques used to label cells for detection of infection and bleeding using nuclear scans for in vivo scanning. Also we are using Technetium instead of FDG which has very little radioactivity allowing us to work with the current cardiac labs with out having to reconstruct the labs with special shielding for radioactive compounds. Real benefit of stem cells then can be explored after demonstrating the proper homing.

Conditions

  • Homing of Stem Cells in the Infarct Area.

Sponsors & Collaborators

  • Indian Council of Medical Research

    collaborator OTHER_GOV

  • All India Institute of Medical Sciences

    lead OTHER

Principal Investigators

  • Sandeep Seth, DM · All India Institute of Medical Sciences

  • Neeraj Parakh, DM · All India Institute of Medical Sciences

  • Chetan Patel · All India Institute of Medical Sciences

  • Sujata Mohanty · All India Institute of Medical Sciences

  • Sneh Lata · All India Institute of Medical Sciences

  • Balram Bhargava, DM · All India Institute of Medical Sciences

  • Vinay Kr Bahl, DM · All India Institute of Medical Sciences

  • Balram Airan, DM · All India Institute of Medical Sciences

Eligibility

Min Age
20 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-08-31
Primary Completion
2017-08-31
Completion
2017-12-31

Countries

  • India

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02148666 on ClinicalTrials.gov