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Hippocampal Sparing Whole Brain Radiotherapy vs Conventional Whole Brain Radiotherapy in Patients With Brain Metastases

NCT02147028 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 23

Last updated 2021-02-25

No results posted yet for this study

Summary

The purpose of this study is to evaluate whether sparing the hippocampi during whole brain radiotherapy following neurosurgery or stereotactic radiosurgery in patients with brain metastases from a systemic tumour helps preserve brain function.

Conditions

Interventions

RADIATION

Hippocampal sparing whole brain radiotherapy

30 Gy in 10 fractions hippocampal sparing whole brain radiotherapy will be administered by Helical Tomotherapy, IMRT, or VMAT

RADIATION

Conventional whole brain radiotherapy

30 Gy in 10 fractions conventional whole brain radiotherapy will be administered

Sponsors & Collaborators

  • Cancer Research UK

    collaborator OTHER

  • The Brain Tumour Charity

    collaborator OTHER

  • University College, London

    lead OTHER

Principal Investigators

  • Gillian Whitfield, MA,MB BS,PhD · The Christie NHS Foundation Trust

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
16 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-08-03
Primary Completion
2018-06-30
Completion
2021-02-16

Countries

  • United Kingdom

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02147028 on ClinicalTrials.gov