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Non-Invasive Cardiac Output Measurement for CRT Optimization

NCT02126241 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 42

Last updated 2015-08-06

No results posted yet for this study

Summary

This proposal aims to evaluate the added clinical and echocardiographic benefit of using the non-invasive impedance-based cardiac output measurement system (NICaS) for optimizing atrio-ventricular and inter-ventricular delays in chronic (more than 6 months) CRT recipients.

Conditions

  • Congestive Heart Failure

Interventions

OTHER

NICaS guided CRT optimization

1. Baseline CO measurement by NICaS 2. AV delay optimization: 1. AV delay will be changed (increase and decrease) by 30 ms steps , and for each new AV value, the CO will be real-time measured by NICaS 2. The AV delay yielding the maximal CO, will be considered the optimal AV delay 3. The device will be programmed using the optimal AV delay 3. VV delay optimization: 1. After Step 2, the baseline VV delay will be changed (increase and decrease; meaning that we will be pacing alternatively the LV before the RV, then the RV before the LV), by 30 ms steps, and for each new VV value, the CO will be real-time measured by NICaS 2. The VV delay yielding the maximal CO, will be considered the optimal VV delay 3. The device will be programmed using the optimal VV delay

Sponsors & Collaborators

  • Sheba Medical Center

    lead OTHER_GOV

Principal Investigators

  • Michael Glikson, MD · Sheba Medical Center

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-04-30
Primary Completion
2014-11-30
Completion
2015-05-31

Countries

  • Israel

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02126241 on ClinicalTrials.gov