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Muscle Blood Flow During Exercise

NCT02070848 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 20

Last updated 2021-03-05

No results posted yet for this study

Summary

Physical exercise triggers various physiological responses including a marked increase in muscle blood flow and oxygen delivery in order to support muscle activity. How muscle blood flow is controlled is currently unclear.

The primary purpose of this study is to establish the respective contribution of metabolic (linked to energy requirements) and mechanical (linked to muscle tensions) signals in the exercise hyperemia and the possible role of the red blood cells.

Vasodilation and muscle blood flow during exercise are controlled by ATP released in the plasma from the red blood cells in response to a combination of metabolic and mechanical signals applied on the vasculature.

Conditions

  • Skeletal Muscle Blood Flow

Interventions

OTHER

Session 1-4

Familiarization sessions to knee-extensor exercise separated by 72h recovery

OTHER

Session 4

After the last familiarization session, 1 maximal incremental test on a bicycle, followed by 72h rest

OTHER

Session 5

2 maximal incremental tests of knee-extension exercise (concentric vs eccentric), separated by 3h rest.

Sponsors & Collaborators

  • University Hospital, Strasbourg, France

    lead OTHER

Principal Investigators

  • Stéphane DOUTRELEAU, MD · Hôpitaux Universitaires de Strasbourg

  • DUFOUR Stéphane, MD · Faculté des Sciences du Sport 14 Rue René Descartes 67084 Strasbourg

  • FAVRET Fabrice, MD · Faculté des Sciences du Sport 14 Rue René Descartes 67084 Strasbourg

  • LONSDORFER Evelyne, MD · Hôpitaux Universitaires de Strasbourg

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-09-01
Primary Completion
2018-10-19
Completion
2018-10-19

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02070848 on ClinicalTrials.gov