Reducing Atrial Pacing Rate to Reduce Atrial Fibrillation in Patients With Sick Sinus Syndrome.

Summary

Atrial fibrillation (AF) is prevalent in patients with sick sinus syndrome (SSS) and associated with an increased risk of stroke and death. Within the first two years after pacemaker implantation almost half of the patients are diagnosed with AF. Studies have indicated that an increased amount of stimulation from the pacemaker in the atria is associated with an increased amount of AF.

The aim of the present study is to test the hypothesis that a reduction of stimulation from the pacemaker in the atria, and reducing the minimal heart rate, increases the time to AF.

Conditions

• Sinus Node Disease
• Atrial Fibrillation

Interventions

DEVICE

DDDR-60

DDDR, lower pacing rate 60 bpm, RR activated (low-moderate)

DEVICE

DDD-40

DDD, lower pacing rate 40 bpm, RR function off

Sponsors & Collaborators

• Aalborg University Hospital

  collaborator OTHER

• Herning Hospital

  collaborator OTHER

• Regionshospitalet Viborg, Skive

  collaborator OTHER

• Aabenraa Hospital

  collaborator OTHER

• Esbjerg Hospital - University Hospital of Southern Denmark

  collaborator OTHER

• Vejle Hospital

  collaborator OTHER

• Odense University Hospital

  collaborator OTHER

• Zealand University Hospital

  collaborator OTHER

• Rigshospitalet, Denmark

  collaborator OTHER

• Bispebjerg Hospital

  collaborator OTHER

• University Hospital, Gentofte, Copenhagen

  collaborator OTHER

• Hillerod Hospital, Denmark

  collaborator OTHER

• Aarhus University Hospital

  lead OTHER

Principal Investigators

• Jens C Nielsen, prof., DMSc, · Department of Cardiology, Aarhus University Hospital

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2014-05-31

Primary Completion

2023-03-31

Completion

2023-03-31

Countries

• Denmark

Study Locations