MedTrace Logo

Genome Transplant Dynamics: Non-invasive Sequencing-based Diagnosis of Rejection

NCT01985412 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 65

Last updated 2019-10-04

No results posted yet for this study

Summary

The purpose of this study is to determine whether shotgun sequencing technology, which can be used to detect donor DNA in recipient plasma, can be used as a rapid, accurate, non-invasive method to detect Acute Cellular Rejection (ACR) after heart transplantation. Currently, all heart transplant recipients undergo invasive heart biopsies to diagnose ACR. Thus, there is an ongoing need to monitor patients for the development of acute and chronic rejection, with the primary goal of non-invasive early detection and treatment to prevent organ damage.

Conditions

  • Cardiac Transplant Rejection
  • Lung Transplant Rejection

Sponsors & Collaborators

Principal Investigators

  • Kiran Khush, MD MAS FACC · Stanford University Hospital and Clinics

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-03-31
Primary Completion
2013-09-29
Completion
2013-09-29

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01985412 on ClinicalTrials.gov