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Characterisation of Circadian Rhythm in Autistic Spectrum Disorder

NCT01984944 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 42

Last updated 2014-11-07

No results posted yet for this study

Summary

Autism spectrum disorders (ASDs) are complex neurodevelopmental conditions characterized by deficits in social communication, delay in language and repetitive behaviors. Results from genetic studies reveal one pathway associated with susceptibility to ASDs, which includes synaptic cell adhesion molecules. Among the factors that could modulate this pathway are the genes controlling circadian rhythms. Sleep disorders and low melatonin levels are frequently observed in ASDs. Thus investigator will characterize the circadian rhythms of patients with ASD and search for circadian rhythms genes polymorphisms.

Conditions

  • Autistic Disorder

Interventions

OTHER

Autistic functional exploration

* 50 adults with urinary sample, core body temperature rhythm, Circadian rhythms assessed with actometer * 25 childs with urinary sample, Circadian rhythms assessed with actometer

OTHER

Control functional exploration

* 50 adults with urinary sample, core body temperature rhythm, Circadian rhythms assessed with actometer * 25 childs with urinary sample, Circadian rhythms assessed with actometer

Sponsors & Collaborators

  • Henri Mondor University Hospital

    collaborator OTHER

  • Albert Chenevier Hospital (Department of Psychiatry)

    collaborator UNKNOWN

  • Hopital Universitaire Robert-Debre

    collaborator OTHER

  • Pasteur Institute (Cognitive Function and Human Genetic)

    collaborator UNKNOWN

  • Fondation FondaMental

    collaborator OTHER

  • Assistance Publique - Hôpitaux de Paris

    lead OTHER

Principal Investigators

  • Xavier DROUOT, MCU-PH · Assistance Publique - Hôpitaux de Paris

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
6 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2009-10-31
Primary Completion
2013-08-31
Completion
2013-08-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01984944 on ClinicalTrials.gov