Primary Hyperaldosteronism and Ischemia-reperfusion Injury
NCT01978132 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40
Last updated 2017-10-12
Summary
Patients with primary hyperaldosteronism experience more cardiovascular events compared to patients with primary hypertension, independent of the blood pressure level.
In this research we hypothesize that patients with primary hyperaldosteronism are more susceptible to ischemia-reperfusion injury.
Conditions
- Primary Hyperaldosteronism
Interventions
- PROCEDURE
-
forearm ischemia and reperfusion
both arms will be subjected to 20 minutes of forearm ischemia and 20 minutes of reperfusion.
Sponsors & Collaborators
-
Radboud University Medical Center
lead OTHER
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- DIAGNOSTIC
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2013-11-30
- Primary Completion
- 2017-05-01
- Completion
- 2017-07-01
Countries
- Netherlands
Study Locations
More Related Trials
-
Renal Sympathetic Denervation From The Adventitia on Hypertension
NCT02642445 ·Status: COMPLETED ·Phase: NA
-
Prevalence of Primary Aldosteronism Among Hypertensive Patients With Atrial Arythmia
NCT04115280 ·Status: COMPLETED ·Phase: NA
-
Long-term Blood Pressure Outcome After Unilateral Adrenalectomy for Primary Hyperaldosteronism
NCT03648294 ·Status: COMPLETED
-
The Dutch National Renal Denervation Registry
NCT02482103 ·Status: UNKNOWN
-
Renal Denervation in Treatment Resistant Hypertension
NCT01762488 ·Status: TERMINATED ·Phase: PHASE3
-
Aldosterone, Microvascular Function and Salt-sensitivity
NCT02068781 ·Status: COMPLETED ·Phase: NA
-
Effect of Plasma Sodium Concentration on Blood Pressure Regulators During Hemodialysis
NCT03578510 ·Status: COMPLETED ·Phase: NA
-
PCI and Renal Denervation in Hypertensive Patients With Acute Coronary Syndromes
NCT02272920 ·Status: UNKNOWN ·Phase: PHASE2
-
Central Hemodynamics
NCT01837784 ·Status: UNKNOWN
-
Reintervention-study After Previous Renal Denervation in Non-responding Patients With Severe Hypertension
NCT01834118 ·Status: COMPLETED
-
Neural Mechanism of Aldosterone-induced Insulin Resistance
NCT02102243 ·Status: WITHDRAWN ·Phase: PHASE4
-
Renal Sympathetic Denervation From the Adventitia on Resistant Hypertension(RSDARH)
NCT03758196 ·Status: UNKNOWN ·Phase: NA
-
The Effect of Renal Denervation on Renal Flow in Humans
NCT01848314 ·Status: COMPLETED ·Phase: NA
-
Renal Sympathetic Denervation as a New Treatment for Therapy Resistant Hypertension
NCT01850901 ·Status: COMPLETED ·Phase: PHASE3
-
Renal Denervation in Patients With Uncontrolled Blood Pressure
NCT01968785 ·Status: TERMINATED ·Phase: NA
-
Prevalence of Primary Aldosteronism in Patients With Resistant Hypertension in China
NCT01459042 ·Status: COMPLETED
-
Renin-angiotensin-aldosterone System Polymorphisms in Resistant Hypertension and Adverse Cardiovascular Events
NCT01173029 ·Status: COMPLETED
-
The Effect of Orally Administrated Nitrate on Renal Parameters and Systemic Haemodynamics
NCT04755400 ·Status: COMPLETED ·Phase: NA
-
Renal Denervation for Treatment of Resistant Hypertension in Patients With Chronic Kidney Disease
NCT01747382 ·Status: NO_LONGER_AVAILABLE
-
Evaluating the Effects of Nitroglycerin on Heart Function and Urinary Output in Patients With Acute Heart Failure
NCT06682260 ·Status: COMPLETED ·Phase: PHASE4
-
New Biomarkers and Difficult-to-treat Hypertension
NCT03034265 ·Status: COMPLETED
-
The Effect of Renal Denervation on Biological Variables
NCT01427049 ·Status: COMPLETED
-
Evaluation of Two Isometric Exercises in the Reduction of the Blood Pressure in People With Resistant Hypertension
NCT06515795 ·Status: RECRUITING ·Phase: NA
-
Renal Artery Denervation Assessment Without Antihypertensive Medication Regimen (RADAR)
NCT07083765 ·Status: SUSPENDED ·Phase: PHASE3
-
Clinical Outcome of Patients With Resistant Hypertension Undergoing Renal Denervation
NCT04722159 ·Status: UNKNOWN