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Genetic Polymorphism of the Androgen Receptor-Gene and Sexual Function in Middle Aged Women

NCT01977313 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 45

Last updated 2015-09-25

No results posted yet for this study

Summary

It is known that with increasing age sexual desire is declining in women. Decreasing levels of androgens are believed to have an influence, but cannot explain the loss of libido completely. A possible explanation might be that the effect of the androgen is depending on the functionality of the androgen receptor. It is known that this functionality is genetically determined by the polymorphism of the androgen receptor gene. In the gene there is a varying number of CAG-repeats: the longer the CAG-Repeat, the lower the functionality of the androgen receptor, the lower the effect of the androgens. In this pilot study, the investigators would like to invite 45 healthy heterosexual middle-aged women to the University Hospital of Bern, where they answer questionnaires about their sexual function and where they give a blood sample to assess the testosterone serum levels and the genetically determined androgen receptor subtype.

The investigators believe that lower androgen levels and/or longer CAG-repeats in the androgen receptor gene are related to lower libido scores in healthy middle-aged women.

Conditions

  • Libido
  • Receptors, Androgen
  • Polymorphism, Genetic
  • Androgen Effect

Sponsors & Collaborators

  • University Hospital Muenster

    collaborator OTHER

  • University of Zurich

    collaborator OTHER

  • Insel Gruppe AG, University Hospital Bern

    lead OTHER

Principal Investigators

  • Petra Stute, PD Dr. med. · Clinic for Gynaecology and Obstetrics, Insel University Hospital Bern, Switzerland

Eligibility

Min Age
45 Years
Max Age
65 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-09-30
Primary Completion
2015-07-31
Completion
2015-07-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01977313 on ClinicalTrials.gov