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Stress Hormones, Mood and Women's Sexual Desire (MODEST)

NCT01702818 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 324

Last updated 2018-10-17

No results posted yet for this study

Summary

Women with Hypoactive sexual desire disorder (HSDD) have all measures of testosterone activity comparable to controls but lower levels of dehydroepiandrosterone (DHEA). Although DHEA is a precursor of testosterone it has other actions including involvement in the stress system. It is also linked to mood. This study focuses on measures of childhood stress, current mood and salivary stress hormones, in women with and without HSDD. We hypothesize that low levels of DHEA reflect dysfunction of the neuroendocrine stress response system involving the brain, pituitary and adrenal glands where DHEA is produced.

Conditions

  • Hypoactive Sexual Desire Disorder (HSDD)

Sponsors & Collaborators

  • University of British Columbia

    lead OTHER

Principal Investigators

  • Rosemary Basson, MD · University of British Columbia

  • Lori A Brotto, PhD · University of British Columbia

Eligibility

Min Age
19 Years
Max Age
65 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-02-29
Primary Completion
2016-11-30
Completion
2016-11-30

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01702818 on ClinicalTrials.gov