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The Effect of Topical Administration of Common Drugs on Postoperative Bleeding and Pain

NCT01964781 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2019-05-17

No results posted yet for this study

Summary

After surgical procedures, interventions to reduce postoperative pain and bleeding are of great importance. In this study, the effect will be investigated of smearing common drugs, which are designed for injection, directly onto the raw wound surface (topical application) created during surgery. Topical application allows a small amount of drug to reach a large wound area, higher drug concentration in the exposed wound surface but very low concentration in the body, and no risk of injury from needles. Although beneficial effects of such an easy and low-cost intervention would be expected, the investigators have found no previous reports on blinded and controlled studies.

Conditions

  • Pain, Postoperative
  • Postoperative Hemorrhage

Interventions

DRUG

Tranexamic Acid

Topical administration - does it reduce surgical bleeding?

DRUG

Bupivacaine

Topical Bupivacaine- does it reduce surgical pain?

DRUG

Adrenaline

Topical adrenaline - does it reduce bleeding on its own, and does it enhance the effect of tranexamic acid?

DRUG

tranexamic acid plus saline

DRUG

saline

Sponsors & Collaborators

  • St. Olavs Hospital

    lead OTHER

Principal Investigators

  • Hilde Pleym, MD PhD · St. Olavs Hospital

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-08-31
Primary Completion
2014-12-31
Completion
2014-12-31

Countries

  • Norway

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01964781 on ClinicalTrials.gov