Short Duration Treatment of Non-severe Community Acquired Pneumonia

Summary

To investigate the non inferiority of a short lasting antibiotic treatment (3 days) when compared to a long lasting antibiotic treatment (8 days), at Day 15 after the beginning of treatment in terms of clinical efficacy, in adults admitted to emergency services for a non severe Community Acquired Pneumonia (PAC), who responded well to 3 days of beta-lactamin treatment (3GC or A/AC).

Conditions

• Community Acquired Pneumonia

Interventions

RADIATION

Chest X-ray

at Day 0, Day 30 and relapse

BIOLOGICAL

blood sampling /Cell Counts/ C reactive protein (CRP)/Biochemistry

DRUG

Augmentin

2 tablets 3 times a day for 5 days from Day 3

DRUG

Placebo (for Augmentin)

2 tablets 3 times a day for 5 days from Day 3

DRUG

Beta-Lactams

administered from Day 0 to Day 3

Sponsors & Collaborators

• Versailles Hospital

  lead OTHER

Principal Investigators

• Anne-Claude CREMIEUX, Pr · Central Hospital Raymon Poincaré

• Marie Christine DOMBRET, Dr · CHU Bichat

• Matthieu GROH, Dr · CHU Cochin

• Elizabeth ROUVEIX, Pr · CHU Ambroise Paré

• Pascale LONGUET, Dr · CH Argenteuil

• Daniel BENHAMOU, Dr · CHU Rouen

• Sylvain DIAMANTIS, Dr · Melun Hospital

• Jean-Emmanuel Kahn, Dr · Foch Hospital

• Jean-François BOITIAUX, Dr · Pontoise Hospital

• Jean-Pierre BEDOS, Pr · Central Hospital of Versailles

• Jêrome PACANOWSKI, Dr · CHU Saint Antoine (Paris)

• Valérie GARRAIT, Dr · CHI CRETEIL

• Elena FOIS, Dr · CH Saint Denis

• Benjamin WYPLOSZ, Pr · CH Bicêtre

• Véronique DELCEY, Dr · CH Lariboisière

• Gilles PIALOUX, Dr · CH Tenon

• Matthieu REVEST, Dr · CHU Rennes Pontchaillou

• Jean Paul STAHL, Dr · University Hospital, Grenoble

• Virginie VITRAT, Dr · CH Annecy Genevois

• Victoire De Lastours, Dr · CH Beaujon

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2013-11-30

Primary Completion

2018-06-30

Completion

2018-06-30

Countries

• France

Study Locations