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Genetic and Other Aspects of Podoconiosis

NCT01939431 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 76

Last updated 2021-01-14

No results posted yet for this study

Summary

Background:

\- Podoconiosis is a disease of the lymph vessels in the legs and feet. It is caused by long-term barefoot exposure to irritant soils, such as those in volcanic areas. It causes severe swelling and disfigurement, as well as infection and chronic pain. It mostly affects people who live in tropical Africa, Central and South America, and India. The reasons why some people develop this disease and others do not is not well understood. Researchers want to study people with the disease and healthy volunteers in Ethiopia. They will collect skin and blood samples to study genetic and other aspects of the disease.

Objectives:

\- To collect skin and blood samples to study genetic and other aspects of podoconiosis.

Eligibility:

* Individuals at least 18 years of age who have podoconiosis (early stage or advanced stage).
* Healthy volunteers at least 18 years of age.
* Participants will be recruited from a study clinic and hospital in Ethiopia.

Design:

* Participants will be screened with a physical exam and medical history.
* Blood samples will be collected. A skin biopsy will be performed to collect tissue for study. People who have podoconiosis will provide affected and unaffected tissue. Healthy volunteers will provide a single skin biopsy sample.
* Treatment will not be provided as part of this study.

Conditions

  • Podoconiosis

Sponsors & Collaborators

  • National Human Genome Research Institute (NHGRI)

    lead NIH

Principal Investigators

  • Charles N Rotimi, M.D. · National Human Genome Research Institute (NHGRI)

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-08-20
Primary Completion
2019-12-30
Completion
2019-12-30

Countries

  • Ethiopia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01939431 on ClinicalTrials.gov