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Genomic Research in Sarcoidosis

NCT01831739 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 368

Last updated 2016-01-12

No results posted yet for this study

Summary

This project is designed to address the following hypothesis:

Distinct patterns in lung microbiome are characteristic of sarcoidosis phenotypes and reflected in changes in systemic inflammatory responses as measured by peripheral changes in gene transcription.

The Specific Aims are:

1. To identify peripheral blood mononuclear cell (PBMC) gene expression patterns that characterize distinct sarcoidosis phenotypes.
2. To determine whether patterns in the lung microbiome are associated with sarcoidosis severity and disease phenotypes
3. To correlate mRNA and microRNA expression patterns in sarcoidosis affected organs with changes in microbiome, clinical parameters and PBMC gene expression patterns
4. To integrate clinical, transcriptomic, and microbiome data to identify novel molecular phenotypes in sarcoidosis.

Conditions

  • Sarcoidosis

Sponsors & Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

    collaborator NIH

  • University of Pittsburgh

    lead OTHER

Principal Investigators

  • Naftali Kaminski, MD · Yale University

  • Stephen Wisniewski, PhD · University of Pittsburgh

  • Michael Becich, MD, PhD · University of Pittsburgh

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-05-31
Primary Completion
2015-06-30
Completion
2015-09-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01831739 on ClinicalTrials.gov