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The Impact of Helicobacter Pylori Infection on Immune Regulation and Clinical Course in HIV Patients in Ghana

NCT01897909 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 1100

Last updated 2021-07-29

No results posted yet for this study

Summary

The main objective of the study is to investigate the impact of H. pylori infection on immune activation and clinical outcome in HIV patients.

Other specific study objectives are:

1. To investigate the effects of H. pylori infection on immune activation and the T-cell profile in HIV positive patients and compare those with HIV negative controls.
2. To assess the influence of H. pylori infection on virological and immune parameters, and on clinical progression of HIV infection (WHO stage, opportunistic infections).
3. To assess the prevalence of H. pylori infection among HIV patients in the Komfo Anokye Teaching Hospital.
4. To assess the prevalence of gastrointestinal symptoms in HIV patients in Kumasi.
5. To assess the association of H. pylori infection with gastrointestinal symptoms and pathology in HIV patients.
6. To compare the clinical and immunological response to antiretroviral therapy and in HIV-patients with and without concomitant H. pylori infection.

Conditions

  • HIV
  • Bacterial Infection Due to Helicobacter Pylori (H. Pylori)

Sponsors & Collaborators

  • Kwame Nkrumah University of Science and Technology

    collaborator OTHER

  • Kumasi Centre for Collaborative Research (KCCR)

    collaborator OTHER

  • Komfo Anokye Teaching Hospital

    collaborator OTHER

  • Universitätsklinikum Hamburg-Eppendorf

    collaborator OTHER

  • Bernhard Nocht Institute for Tropical Medicine

    lead OTHER_GOV

Principal Investigators

  • Torsten Feldt, MD · Bernhard Nocht Institute for Tropical Medicine

  • Kirsten A Eberhardt, MD · Bernhard Nocht Institute for Tropical Medicine

  • Fred S Sarfo, FWACP, PHD · Kwame Nkrumah University of Science and Technology

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-11-30
Primary Completion
2021-07-29
Completion
2021-07-29

Countries

  • Ghana

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01897909 on ClinicalTrials.gov