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Viral and Immunologic Factors Contributing to the Lack of HIV Transmission Among Couples in Rakai, Uganda

NCT00342160 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 88

Last updated 2019-12-16

No results posted yet for this study

Summary

This study will look at viral and immunologic factors involved in protecting against sexually transmitted HIV infection in couples in which one partner is infected and the other is not.

This study will include 50 couples who reside in Rakai, Uganda, and who have been together for at least 2 years. In some couples, both partners will be HIV-infected, in some couples only one partner will have HIV, and in some couples neither partner will have HIV.

Participants undergo the following procedures at each of four study visits:

* HIV counseling and testing
* Medical history, including questions about personal behaviors such as sexual practices and use of condoms
* Blood sample collection
* Urine sample collection
* Vaginal swab for women

Blood, urine and vaginal fluid samples are tested for HIV and other sexually transmitted diseases, such as syphilis. Blood and vaginal samples are also tested for HIV viral levels and immune response in HIV-infected individuals and for evidence of exposure to HIV in non-infected participants. Some blood is also tested for genetic markers to investigate whether certain proteins are related to resistance to HIV infection.

...

Conditions

Sponsors & Collaborators

  • National Institute of Allergy and Infectious Diseases (NIAID)

    lead NIH

Principal Investigators

  • Thomas C Quinn, M.D. · National Institute of Allergy and Infectious Diseases (NIAID)

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2006-02-15
Completion
2012-11-13

Countries

  • Uganda

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00342160 on ClinicalTrials.gov