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Observational Study of Blood Glucose Levels and Gut Microbiota in Healthy Individuals

NCT01892956 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 2000

Last updated 2020-06-23

No results posted yet for this study

Summary

Categorization of glucose levels into 'healthy', 'pre-diabetic' or 'diabetic' is increasingly seen as artificial. Furthermore, most micro and macrovascular complications may be present already at the pre-diabetic stage.

Hyperglycemia, pre-diabetes and impaired glucose tolerance (IGT) are fully reversible, thus, maintaining normal blood sugar levels is crucial for the prevention and control of diabetes and the various other consequences of the metabolic syndrome. Only interventions that are individually tailored can achieve proper glycemic control, and the glycemic index (GI), which quantifies the glycemic response to particular foods, was developed for this purpose.

In this study the investigators will characterize the blood glucose responses and microbiota of healthy individuals, aiming to assess the influence of food intake on gut microbiota and the influence of gut microbiota on glycemic responses.

Conditions

  • Nutritional and Metabolic Diseases
  • Endocrine System Diseases
  • Disorders of Environmental Origin

Interventions

OTHER

Nutritional intervention

2 dietary interventions 1. personalized diet based on algorithm predictions of glucose response to foods 2. Mediterranean-style diet

Sponsors & Collaborators

  • Weizmann Institute of Science

    collaborator OTHER

  • Tel-Aviv Sourasky Medical Center

    lead OTHER_GOV

Principal Investigators

  • Zamir Halpern, MD · Tel-Aviv Sourasky Medical Center

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-04-30
Primary Completion
2015-04-30
Completion
2019-10-30

Countries

  • Israel

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01892956 on ClinicalTrials.gov