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Effect of Catheter-based Radiofrequency Ablation Therapy in Patient With Therapy-resistant Hypertension and Sleep Apnea Syndrome

NCT01879566 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2017-10-25

No results posted yet for this study

Summary

The aim of this prospective single-center study is to evaluate sympathetic nervous system directly measured by microneurography, 24-hour blood pressure, endothelial function, vascular compliance, quality of life and platelet adhesion in patients with sleep apnea syndrome (defined by a complaint of excessive daytime sleepiness, an Epworth sleepiness score\>8\[10\], and an apnea/hypopnea index (AHI\>15/h) before and after catheter-based radiofrequency ablation of renal nerve. If the selected patients are treated with CPAP, this therapy should be stable during the whole study time. Primary and secondary end-point will be measured before and 1, 3, 6 and 12 months after renal sympathetic denervation.

Conditions

  • Therapy-resistant Hypertension and Sleep Apnea

Interventions

OTHER

No intervention will be done. The study is observational

Sponsors & Collaborators

  • University of Zurich

    lead OTHER

Principal Investigators

  • Thomas Luescher, Professor, MD · University Hospital Zurich, Division of Cardiology

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-05-31
Primary Completion
2017-04-30
Completion
2017-07-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01879566 on ClinicalTrials.gov