Artemisinin Resistance in Cambodia
NCT00479206 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL
Last updated 2008-04-30
Summary
The principal aim of this project is to investigate reports of developing artemisinin resistance in Cambodia using an integrated in vivo - in vitro approach to examine recent alarming reports of treatment failures with advanced combination therapies along the Thai-Cambodian border, which could have major impact on the malaria situation in the affected areas as well as the rest of the malaria-endemic world.
Conditions
- Malaria, Falciparum
Interventions
- DRUG
-
Artesunate
Sponsors & Collaborators
-
Global Emerging Infections Surveillance and Response System
collaborator FED -
Armed Forces Research Institute of Medical Sciences, Thailand
collaborator OTHER_GOV -
National Center for Parasitology, Entomology and Malaria Control
collaborator UNKNOWN -
Medical University of Vienna
lead OTHER
Principal Investigators
-
Harald Noedl, MD, MCTM, PhD · USAMC-AFRIMS
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Max Age
- 65 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2006-10-31
- Completion
- 2007-02-28
Countries
- Cambodia
More Related Trials
-
Rigorous Assessment of P. Vivax Relapses and Primaquine Efficacy for Radical Cure
NCT04706130 ·Status: COMPLETED ·Phase: PHASE4
-
Plasmodium Falciparum Clearance Rates in Response to Artesunate in Eastern Cambodia
NCT01240603 ·Status: COMPLETED
-
Efficacy of Artesunate-Mefloquine Combination Therapy in Trat Province, Thailand
NCT01659281 ·Status: COMPLETED ·Phase: NA
-
Artemisinin Resistance In Malaria Treated With IV Artesunate
NCT02640495 ·Status: WITHDRAWN
-
Study to Assess Efficacy of Artemether-lumefantrine Prophylaxis Against Forest Malaria in Cambodia (PAL_Cambodia)
NCT04041973 ·Status: COMPLETED ·Phase: NA
-
Molecular Surveillance of Artemisinin Resistance Malaria in Myanmar
NCT02792816 ·Status: COMPLETED
-
In Vivo and In Vitro Efficacy of Artemisinin Combination Therapy
NCT01976780 ·Status: COMPLETED ·Phase: PHASE4
-
Effectiveness of Artemisinin Combination Regimens in Falciparum Malaria
NCT00902811 ·Status: UNKNOWN ·Phase: PHASE4
-
Plasmodium Falciparum Artemisinin Resistance Vietnam
NCT01775592 ·Status: COMPLETED ·Phase: PHASE4
-
A Randomized Trial of Coartemether and Artekin for the Treatment of Uncomplicated Malaria in Papua, Indonesia.
NCT00157833 ·Status: COMPLETED ·Phase: NA
-
Study to Compare the Triple ACT AL+AQ With the ACT AL in Cambodia and Vietnam
NCT03355664 ·Status: COMPLETED ·Phase: PHASE3
-
Artemisone for the Treatment of Uncomplicated Falciparum Malaria in Western Cambodia
NCT00936767 ·Status: WITHDRAWN ·Phase: PHASE2/PHASE3
-
Triple Artemisinin-based Combination Therapy for Delaying Drug Resistance Development - a Randomized Clinical Trial
NCT05764746 ·Status: RECRUITING ·Phase: PHASE2/PHASE3
-
The ASAP Study - Therapeutic Efficacy of Atovaquone-proguanil vs. Artesunate-atovaquone-proguanil in Cambodia
NCT02297477 ·Status: UNKNOWN ·Phase: PHASE4
-
P. Falciparum Resistance to Artemisinin in Vietnam
NCT02604966 ·Status: UNKNOWN ·Phase: PHASE4
-
A Trial to Compare the Efficacy, Safety and Tolerability of Combinations of 3 Anti-malarial Drugs Against Combinations of 2 Anti-malarial Drugs (Asia)
NCT03939104 ·Status: COMPLETED ·Phase: PHASE3
-
Safety and Efficacy Dose of Artesunate Used in Combination With LAPDAP Treatment of Uncomplicated Falciparum Malaria
NCT00519467 ·Status: COMPLETED ·Phase: PHASE2
-
Study on the Treatment of Vivax Malaria
NCT01074905 ·Status: COMPLETED ·Phase: PHASE3
-
Harmonized AS/MQ Efficacy Study - Thailand
NCT02052323 ·Status: COMPLETED ·Phase: PHASE4
-
Malaria Genetic Surveillance in Cambodia
NCT03384472 ·Status: COMPLETED
-
Efficacy of Artesunate-amodiaquine and Artemether-lumefantrine for Uncomplicated Malaria in South Kivu, DR Congo
NCT02741024 ·Status: COMPLETED ·Phase: PHASE4
-
Efficacy Study of Amodiaquine-Artesunate and Artemether-Lumefantrine for the Treatment of Uncomplicated Malaria
NCT01567423 ·Status: COMPLETED ·Phase: NA
-
Artemisinin-Based Combination Therapy: Clinical Trials in Cameroon
NCT00297882 ·Status: COMPLETED ·Phase: PHASE3
-
Safety and Efficacy of Recommended Antimalarial in the Democratic Republic of the Congo
NCT04618523 ·Status: COMPLETED ·Phase: PHASE4
-
Efficacy and Safety of Artesunate-amodiaquine and Artemether-lumefantrine for the Treatment of Malaria in Cameroon
NCT04829695 ·Status: UNKNOWN ·Phase: PHASE4