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Investigating Hereditary Cardiac Disease by Reprogramming Skin Cells to Heart Muscle

NCT01865981 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 2

Last updated 2020-07-07

No results posted yet for this study

Summary

Hereditary cardiac arrhythmias (genetically caused disturbances of heart rhythm) are life threatening conditions affecting otherwise healthy young individuals. Due to the inaccessibility of heart tissue, the abnormal electrical current(s) in the heart cells causing the rhythm disturbance can be difficult to study in detail and therefore in many cases remain untreatable. The investigators propose to study heart cell electrical function from such patients by reprogramming skin cells to become stem cells and then differentiating them to heart muscle cells.

The hypothesis of the study is that the differentiated cardiac cells will display electrical abnormalities dependent on the mutation causing the disease. These abnormalities can therefore provide a clue as to the nature of the mutation causing the disease or information about its effective management

Conditions

  • Eletrophysiology of iPS-derived Cardiomyocytes

Sponsors & Collaborators

  • University of Dundee

    lead OTHER

Principal Investigators

  • Marios P Stavridis, PhD · University of Dundee

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-06-30
Primary Completion
2017-06-01
Completion
2017-06-01

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01865981 on ClinicalTrials.gov