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Adrenocortical Functions in Women With Nonclassical 21-hydroxylase Deficiency.

NCT01862380 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 41

Last updated 2016-09-29

No results posted yet for this study

Summary

The risk of adrenal insufficiency in patients with nonclassical congenital adrenal hyperplasia due to 21-hydroxylase deficiency is not well documented. Indication of cortisol replacement therapy in situation of acute stress or at long term is thus controversial. The mineralocorticoid reserve of these patients has never been evaluated.

Hypothesis: The glucocorticoid and mineralocorticoid function of the adrenal glands in women with nonclassical 21-hydroxylase deficiency is comparable with the adrenal functions of healthy age- sexe- and BMI-matched subjects.

Conditions

  • Adrenal Hyperplasia, Congenital
  • 21-hydroxylase Deficiency

Interventions

OTHER

Functional explorations

Functional explorations of cortisol and aldosterone production during stimulation by ITT and sodium depletion respectively

OTHER

Functional explorations

Functional explorations of cortisol and aldosterone production during stimulation by ITT and sodium depletion respectively

Sponsors & Collaborators

  • Assistance Publique - Hôpitaux de Paris

    lead OTHER

Principal Investigators

  • Peter Kamenicky, MD, PhD · Assistance Publique Hôpitaux de Paris - Bicêtre Hospital

Study Design

Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-02-28
Primary Completion
2015-12-31
Completion
2016-11-30

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01862380 on ClinicalTrials.gov