Efficacy of Amlodipine-folic Acid Tablets on Reduction of Blood Pressure and Plasma Homocysteine

Summary

To evaluate the efficacy of Amlodipine-folic Acid Tablets on reduction of blood pressure and plasma homocystein.

Conditions

• Essential Hypertension

Interventions

DRUG

Amlodipine

amlodipine 5mg daily

DRUG

amlodipine-FA tablet, low dose group

5mg amlodipine combined with 0.4 mg of folic acid, daily.

DRUG

amlodipine-FA tablet ,high dose group

amlodipine 5mg and folic acid 0.8mg daily

Sponsors & Collaborators

• Peking University First Hospital

  collaborator OTHER

• Chinese PLA General Hospital

  collaborator OTHER

• Capital Medical University

  collaborator OTHER

• Fudan University

  collaborator OTHER

• Ruijin Hospital

  collaborator OTHER

• Nanchang University

  collaborator OTHER

• First Affiliated Hospital of Fujian Medical University

  collaborator OTHER

• First Affiliated Hospital of Harbin Medical University

  collaborator OTHER

• China Medical University, China

  collaborator OTHER

• Xi'an Jiaotong University

  collaborator OTHER

• Xuzhou Medical University

  collaborator OTHER

• Anhui Medical University

  collaborator OTHER

• Huazhong University of Science and Technology

  collaborator OTHER

• West China Hospital

  collaborator OTHER

• Guangdong Provincial People's Hospital

  collaborator OTHER

• Second Affiliated Hospital, School of Medicine, Zhejiang University

  collaborator OTHER

• Shenzhen Ausa Pharmed Co.,Ltd

  lead INDUSTRY

Principal Investigators

• Yong Huo, MD · Peking University First Hospital, Beijing, CHINA

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2013-01-31

Primary Completion

2013-08-31

Completion

2013-08-31

Countries

• China

Study Locations