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Cognitive, Academic and Psychosocial Functioning in Long-Term Survivors of Pediatric Stem Cell Transplantation

NCT01701492 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 133

Last updated 2018-05-18

No results posted yet for this study

Summary

This is an observational study to collect information by use of performance-based measures and survey questionnaires. It does not include interventions aimed at altering patient outcome.

Advances in pediatric hematopoietic stem cell transplantation (SCT) have resulted in improved survival and prompted increased attention to the potential adverse late effects of this procedure. Survivors of SCT are thought to be at risk for neurocognitive deficits as a result of their exposure to a number of potentially neurotoxic agents. Prior studies done by our group and others have demonstrated generally stable cognitive function in the first 5 years following transplant, with little evidence of significant declines. However, there has been almost no research to date on the status of very long-term (\> 5 years post-transplant) survivors. In this study, we will evaluate a large sample of long-term survivors of allogeneic SCT using measures of intelligence, academic achievement, and specific cognitive functions such as attention, working memory and processing speed. We will also obtain measures of behavioral functioning and quality of life. We will examine how this group of survivors are functioning relative to normative expectations, and in comparison to community controls without a history of serious illness, matched on age, gender, race/ethnicity, and socioeconomic status. We will also examine the relationship between cognitive function and psychosocial function and quality of life in this population.

Conditions

  • Stem Cell Transplant During Childhood
  • Allogeneic Bone Marrow Transplant During Childhood

Interventions

OTHER

Questionnaire

A one-time assessment using both performance-based measures as well as both self- and parent-report questionnaires.

OTHER

Neurocognitive Evaluation

A one-time neurocognitive evaluation conducted in the Psychology Clinic

Sponsors & Collaborators

Principal Investigators

  • Sean Phipps, PhD · St. Jude Children's Research Hospital

Eligibility

Min Age
8 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-10-19
Primary Completion
2018-01-23
Completion
2018-01-23

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01701492 on ClinicalTrials.gov