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Comparison of Vascular Function in Emergency Service Professionals

NCT01813032 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 36

Last updated 2024-05-03

No results posted yet for this study

Summary

Emergency Service Professionals have an increased risk of death from heart attacks when compared to the general public. All the emergency professions share similar responsibilities such as emergency call-outs and shift work. Heart disease is the commonest cause of on-duty death amongst fire-fighters accounting for 45% and compared with 22% in police officers and 15% in the general population. The unique risk to fire-fighters is likely to reflect a combination of factors including extreme physical exertion, mental stress, heat and pollutant exposure.

In this study the investigators will assess healthy career fire-fighters and age-matched healthy police officer control subjects following a sedentary period. The investigators will take blood samples to measure platelet activity (platelets are the particles in blood that help blood clot) and will examine how blood clots outside of the body. The investigators will then perform studies placing small needles in the arm to assess how the blood vessels respond following these duties. The investigators hypothesise that fire-fighters do not have pre-existing impairment of heart, blood or blood vessel function as a cumulative effect of their occupation, but rather these are acute and transitory effects following distinct fire-fighter duties. We therefore expect similar results in both occupational groups.

Conditions

  • Vascular Function
  • Atherothrombosis

Interventions

PROCEDURE

Forearm Vascular Study

Forearm venous occlusion plethysmography to measure forearm blood flow during intra-arterial infusion of the vasodilators Verapamil (10-100 µg/min), bradykinin (100-1000 pmol/min), sodium nitroprusside (2-8 µg/min) and Acetylcholine (5-20 µg/min).

PROCEDURE

Badimon Chamber

Ex-vivo assessment of thrombus formation using the Badimon Chamber

Sponsors & Collaborators

  • University of Edinburgh

    lead OTHER

Principal Investigators

  • David E Newby, MD PhD · University of Edinburgh

  • Nicholas L Mills, MBChB PhD · University of Edinburgh

  • Amanda L Hunter, MBChB · University of Edinburgh

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-04-30
Primary Completion
2013-04-30
Completion
2013-04-30

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01813032 on ClinicalTrials.gov