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Immunization With Plasmodium Falciparum Sporozoites Under Chloroquine or Chloroquine/Azithromycin Prophylaxis

NCT01783340 · Status: WITHDRAWN · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL

Last updated 2014-11-13

No results posted yet for this study

Summary

This study will assess the superior protective immunity of the combination of chloroquine and azithromycin prophylaxis under Chemoprophylaxis Sporozoites (CPS) immunization versus a standard chloroquine prophylactic regimen.

Conditions

  • Malaria, Falciparum

Interventions

DRUG

Azithromycin capsules

Azithromycin capsules will be administered at each immunization

DRUG

Placebo

Placebo capsules will be administered at each immunization

BIOLOGICAL

Immunization with falciparum

three inoculations with 5 infected mosquito bites

Sponsors & Collaborators

  • Leiden University Medical Center

    collaborator OTHER

  • Medicines for Malaria Venture

    collaborator OTHER

  • Radboud University Medical Center

    lead OTHER

Principal Investigators

  • RW Sauerwein, MD PhD · Radboud University Medical Center

  • LG Visser, MD PhD · Leiden University Medical Centre

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-04-30
Primary Completion
2013-12-31
Completion
2014-04-30

Countries

  • Netherlands

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01783340 on ClinicalTrials.gov