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To Evaluate Current Efficacy of Antimalarials Used in Timika, Papua, Indonesia

NCT00157859 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 150

Last updated 2005-09-12

No results posted yet for this study

Summary

Multidrug resistant strains of P.falciparum and P.vivax are becoming increasingly prevalent in the Asia Pacific rim. To determine the efficacy of locally recommended antimalarial protocols in Papua, Indonesia, consecutive patients presenting to a rural clinic were enrolled into a prospective efficacy study. Patients with uncomplicated falciparum malaria were treated with chloroquine plus sulfadoxine-pyrimethamine and those with vivax malaria with chloroquine monotherapy. Patients failing therapy received unsupervised oral quinine +/- doxycycline for 7 days. Follow-up was continued for 42 days for falciparum malaria and 28 days for vivax malaria.

The study hypothesis was that current recommended antimalarial protocols were no longer effective.

Conditions

  • Falciparum Malaria
  • Vivax Malaria

Interventions

DRUG

Chloroquine and sulphadoxine-pyrimethamine

Sponsors & Collaborators

  • Wellcome Trust

    collaborator OTHER

  • National Health and Medical Research Council, Australia

    collaborator OTHER

  • National Institute of Health Research and Development, Ministry of Health Republic of Indonesia

    collaborator OTHER

  • Menzies School of Health Research

    lead OTHER

Principal Investigators

  • Emiliana Tjitre, PhD · National Institute of Health Research and Development, Ministry of Health Republic of Indonesia

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
12 Months
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2004-04-30
Completion
2004-09-30

Countries

  • Indonesia

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00157859 on ClinicalTrials.gov