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Mathematical Modeling to Determine Basic Muscle Properties in the Failing Heart

NCT01778894 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 37

Last updated 2023-08-29

No results posted yet for this study

Summary

According to the most recent information released by the American Heart Association, heart failure affects 5.8 million Americans and over 23 million people worldwide. In particular, diastolic heart failure (DHF) has emerged in approximately half of those suffering from heart disease and has become a major public health problem for many reasons, including the complexity of the disease, lack of effective drugs/therapies, requirement of invasive tests to diagnose and monitor DHF, and the absence of a suitable scientific model to study the disease. Scientists and physicians alike still do not fully understand what happens to the muscles in the heart (myocardium) patients who present with diastolic dysfunction or DHF. Therefore, the medical field is in need of an accurate model that can evaluate how diastolic dysfunction leads to heart failure and what happens at a cellular level as this disease emerges and progresses.

Conditions

  • Diastolic Heart Failure

Sponsors & Collaborators

  • University of Nebraska

    lead OTHER

Principal Investigators

  • Moulton J Moulton, MD · University of Nebraska

Eligibility

Min Age
19 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-09-01
Primary Completion
2022-02-03
Completion
2022-02-03

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01778894 on ClinicalTrials.gov