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Can Creatine Supplementation Improve Body Composition and Physical Function in Rheumatoid Arthritis Patients?

NCT01767844 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 43

Last updated 2014-12-03

No results posted yet for this study

Summary

Rheumatoid arthritis (RA) patients typically experience a significant loss of muscle. In healthy individuals, food supplementation with creatine (Cr) increases muscle size and improves physical function and quality of life. The aim of this study is to investigate whether RA patients may benefit similarly.

50 participants will be given a food supplement to take for 12 weeks; this supplement will either be creatine or a placebo (a regular fruit flavoured powder that has no benefits).

Over 12 weeks, body fat and muscle size (body composition), physical function, and fitness (aerobic capacity of the heart and lungs to transport oxygen to the exercising muscles) will be tested. In addition, quality of life questionnaires will be completed, disease activity will be assessed and blood samples will be taken. Muscle samples (muscle biopsy) will be obtained, from those who volunteer to provide them, at baseline and post-treatment.

Conditions

Interventions

DIETARY_SUPPLEMENT

Creatine

Creatine, often found in meat and fish, make up an essential part of the systems that provide energy to the muscles for movement and exercise.

DIETARY_SUPPLEMENT

Placebo

Sponsors & Collaborators

  • Bangor University

    lead OTHER

Principal Investigators

  • Andrew B Lemmey, Prof. · Bangor University

  • Thomas O'Brien, Dr · Bangor University

  • Thomas J Wilkinson · Bangor Unversity

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-01-31
Primary Completion
2015-02-28
Completion
2015-02-28

Countries

  • United Kingdom

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01767844 on ClinicalTrials.gov