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Brain Nicotine Receptor Density in Veteran Smokers

NCT01721473 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 184

Last updated 2019-10-07

Study results available
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Summary

Cigarette smoking is more prevalent among Veterans (27%) than the general U.S. population (21%). Smoking is common among people who use marijuana or caffeine heavily, and the use of menthol cigarettes is becoming increasingly common, affecting approximately 9% of the Veteran population. Recent research by the group and others indicates that heavy marijuana or caffeine use, or the use of predominantly menthol cigarettes, can alter brain nicotinic acetylcholine receptor (nAChR) densities. For the proposed study, brain imaging with PET scanning will be used to determine nicotine receptor densities in Veteran cigarette smokers with and without heavy marijuana or caffeine use, and in menthol and non-menthol Veteran smokers. Results of the proposed research may have implications for improving treatments for Veterans who smoke cigarettes and who have specific drug use co-morbidities or who use menthol cigarettes.

Conditions

  • Positron Emission Tomography

Interventions

OTHER

positron emission tomography scan

2-FA positron emission tomography scan

Sponsors & Collaborators

  • VA Office of Research and Development

    lead FED

Principal Investigators

  • Arthur L Brody, MD · VA San Diego Healthcare System, San Diego, CA

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-01-01
Primary Completion
2016-06-30
Completion
2016-06-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01721473 on ClinicalTrials.gov