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Varenicline on Reward Responses and Cognition in Adolescent Smokers

NCT01624428 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 16

Last updated 2014-02-03

No results posted yet for this study

Summary

This is a pilot project using functional magnetic resonance imaging (fMRI) to examine the influence of varenicline on reward processing, cognitive control, and regulation of craving in adolescent smokers. We hypothesize that adolescent smokers receiving varenicline, when compared with those receiving placebo, will have differential brain responses to anticipation of rewards, during exposure to the Stroop task, and in response to tobacco cues.

Conditions

  • Tobacco Use Disorders

Interventions

DRUG

Varenicline

1 mg bid varenicline titrated over a 2 week period

DRUG

Placebo

1 mg bid placebo titrated over a 2 week period

Sponsors & Collaborators

  • Yale University

    lead OTHER

Principal Investigators

  • Suchitra Krishnan-Sarin, Ph.D. · Yale University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
16 Years
Max Age
19 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-06-30
Primary Completion
2013-11-30
Completion
2013-12-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01624428 on ClinicalTrials.gov