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The Effects of Craving and Abstinence From Cigarettes on Brain Metabolism in Smokers

NCT00267813 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2008-05-07

No results posted yet for this study

Summary

Craving and withdrawal from smoking cigarettes are major factors for relapse. We investigated craving for cigarettes in smokers undergoing pharmacological treatment with Bupropion (Zyban). We compare cue-induced reactivity to smoking videos in smokers who were successfully treated with Bupropion to smokers who are still smoking. We measured the brain's metabolic activity in response to smoking and neutral cues in Positron Emission Tomography using FDG.

Conditions

  • Nicotine Dependence

Interventions

DRUG

Bupropion (Zyban)

1 tablet a day increasing to 2 tablets a day after a week

Sponsors & Collaborators

  • Tel-Aviv Sourasky Medical Center

    lead OTHER_GOV

Principal Investigators

  • Einat Even-Sapir, M.D, Ph.D · Tel-Aviv Sourasky Medical Center

  • Aviv M Weinstein, Ph.D · Tel-Aviv Sourasky Medical Center

  • Hedva Lerman, M.D · Tel-Aviv Sourasky Medical Center

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
20 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2004-07-31
Primary Completion
2007-10-31
Completion
2007-10-31

Countries

  • Israel

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00267813 on ClinicalTrials.gov