Role of the Renin Angiotensin Aldosterone System in the Mechanisms of Transition to Heart Failure in Abdominal Obesity

Summary

R2C2 study has shown that abdominal obesity is associated with a cardiac and vascular remodelling in healthy volunteers. This remodelling is correlated with renin-angiotensin aldosterone system (RAAS) activation and/or systemic fibrosis. R2C2 II study is designed to confirm the hypothesis that RAAS is associated with an early remodelling and implicated in the transition to cardiac failure in abdominal obesity.

Conditions

• Obesity, Abdominal

Interventions

OTHER

Urine sample

dosages on one spot and 24h collection

OTHER

Blood sample

dosages

OTHER

Assessment of sleep apnea syndrome

OTHER

Electrocardiogram

OTHER

Glucose tolerance test

OTHER

Echocardiography

OTHER

cardiac and abdominal magnetic resonance imaging

OTHER

Ambulatory blood pressure monitoring

OTHER

Echotracking

OTHER

Pulse wave velocity

OTHER

Composition of body mass by Dual x-ray absorptiometry

Sponsors & Collaborators

• Central Hospital, Nancy, France

  lead OTHER

Principal Investigators

• Patrick ROSSIGNOL · CIC-P - INSERM - Institut Lorrain du Cœur et des vaisseaux Louis Mathieu

Study Design

Allocation

NA

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

43 Years

Max Age

72 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2012-11-30

Primary Completion

2015-03-31

Completion

2015-03-31

Countries

• France

Study Locations