MedTrace Logo

Role of CVVH in Patients With Acute Paraquat Poisoning

NCT01709604 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 110

Last updated 2016-06-14

No results posted yet for this study

Summary

Paraquat poisoning is characterized by multiple organ failure and pulmonary fibrosis with respiratory failure. Accumulating evidence suggested that continuous venovenous hemofiltration (CVVH) had a beneficial role in the treatment of multiple organ dysfunction. The investigators hypothesized that CVVH might restore multiple organ function and reduce the high mortality rate of paraquat poisoning. To confirm it, an prospective clinical study would be carried out.

Conditions

  • Poisoning by Paraquat With Undetermined Intent

Interventions

PROCEDURE

CVVH

Ultrafiltration at 35ml/h/Kg

PROCEDURE

Standardized therapy regimens

Standardized therapy regimens included the followings: 1. Remove all contaminated clothing 2. Gastric lavage 3. Receive activated charcoal as quickly as possible 4. Hemoperfusion with activated charcoal(160g) 5. Immunosuppression with methylprednisolone 6. Antioxidants (glutathione,1.2 gram iv twice a day) 7. Supportive care

Sponsors & Collaborators

  • Ai Peng

    lead OTHER

Principal Investigators

  • Ai Peng, Ph.D., M.D. · Shanghai 10th People's Hospital

Eligibility

Min Age
14 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-10-31
Primary Completion
2016-06-30
Completion
2016-06-30

Countries

  • China

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01709604 on ClinicalTrials.gov