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Effect of Systemic Hypoxia and Hyperoxia on Retinal Oxygen Saturation

NCT01692821 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2013-01-30

No results posted yet for this study

Summary

Adequate perfusion and oxygenation is essential for the function of the inner retina. Although it is known that oxygen tension is very well autoregulated in the retina, the physiological mechanisms behind this regulation process are not fully explored. The development of new instruments for the non-invasive measurement of oxygen tension in retinal vessels now allows for the more precise investigation of these physiological processes. The current study seeks to evaluate the retinal oxygen saturation in healthy subjects while breathing different oxygen mixtures to achieve a hypoxic and a hyperoxic state.

Conditions

  • Retinal Oxygenation
  • Retinal Blood Flow

Interventions

DRUG

100% oxygen breathing

100% oxygen breathing - 30 minutes

DRUG

15% oxygen in N2 breathing

15% oxygen in N2 breathing - 30 minutes

DRUG

12% oxygen in N2 breathing

12% oxygen in N2 breathing - 30 minutes

Sponsors & Collaborators

  • Medical University of Vienna

    lead OTHER

Principal Investigators

  • Gerhard Garhöfer, Assoc. Prof. Priv.-Doz. Dr. · Department of Clinical Pharmacology, Medical University of Vienna

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-06-30
Primary Completion
2012-12-31
Completion
2013-01-31

Countries

  • Austria

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01692821 on ClinicalTrials.gov