A Dose-Escalation Study in Participants With Recurrent Malignant Glioma
NCT01682187 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 66
Last updated 2024-11-07
Summary
This is a study of oral LY2157299 as monotherapy and in combination with lomustine in participants with recurrent malignant glioma.
Conditions
Interventions
- DRUG
-
LY2157299
Administered orally
- DRUG
-
Lomustine
Administered orally
Sponsors & Collaborators
- lead INDUSTRY
Principal Investigators
-
Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST) · Eli Lilly and Company
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2005-12-15
- Primary Completion
- 2012-05-22
- Completion
- 2024-09-30
Countries
- United States
- Spain
Study Locations
More Related Trials
-
Ph II Erlotinib + Sirolimus for Pts w Recurrent Malignant Glioma Multiforme
NCT00672243 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of Berubicin in Adult Subjects With Recurrent Glioblastoma Multiforme
NCT04762069 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Enzastaurin Versus Lomustine in Glioblastoma
NCT00295815 ·Status: COMPLETED ·Phase: PHASE3
-
A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma
NCT04166409 ·Status: RECRUITING ·Phase: PHASE3
-
Erlotinib and Sirolimus in Treating Patients With Recurrent Malignant Glioma
NCT00509431 ·Status: COMPLETED ·Phase: PHASE1
-
Study of CCNU (Lomustine) Plus Dasatinib in Recurrent Glioblastoma (GBM)
NCT00948389 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Studies of Chlorogenic Acid for Injection for Safety and Efficacy of Grade IV GBM Patients
NCT03758014 ·Status: UNKNOWN ·Phase: PHASE2/PHASE3
-
EMD 121974 in Treating Patients With Progressive or Recurrent Glioma
NCT00006093 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Open-Label Study of I-131-CLR1404 in Subjects With Recurrent Glioma
NCT01778088 ·Status: WITHDRAWN ·Phase: PHASE2
-
Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma
NCT01089101 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
A Study to Compare Treatment With the Drug Selumetinib Alone Versus Selumetinib and Vinblastine in Patients With Recurrent or Progressive Low-Grade Glioma
NCT04576117 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Cilengitide (EMD 121974) for Recurrent Glioblastoma Multiforme (Brain Tumor)
NCT00093964 ·Status: COMPLETED ·Phase: PHASE2
-
Laser Interstitial Thermal Therapy and Lomustine in Treating Patients With Recurrent Glioblastoma or Anaplastic Astrocytoma
NCT03022578 ·Status: TERMINATED ·Phase: PHASE2
-
Lonafarnib and Temozolomide in Treating Patients With Recurrent Primary Supratentorial Gliomas
NCT00083096 ·Status: UNKNOWN ·Phase: PHASE1
-
Everolimus With and Without Temozolomide in Adult Low Grade Glioma
NCT02023905 ·Status: TERMINATED ·Phase: PHASE2
-
A Phase I/II Trial of BMS-247550 for Treatment of Patients With Recurrent High-Grade Gliomas
NCT00045708 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
SCH-900105 in Recurrent Glioblastoma
NCT01189513 ·Status: WITHDRAWN ·Phase: PHASE1
-
A Phase 1b/2, Multicenter, Open-label Study of ACP-196 in Subjects With Recurrent Glioblastoma Multiforme (GBM)
NCT02586857 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
Study of IV Edotecarin Vs Temozolomide or Carmustine (BCNU) or Lomustine (CCNU) in Patients With Glioblastoma Multiforme
NCT00068952 ·Status: COMPLETED ·Phase: PHASE3
-
A Study of MEDI-575 in Subjects With Recurrent Glioblastoma Multiforme
NCT01268566 ·Status: COMPLETED ·Phase: PHASE2
-
Procarbazine and Lomustine in Recurrent Glioblastoma
NCT01737346 ·Status: UNKNOWN ·Phase: PHASE2
-
Study of Lenalidomide and XRT in Patients With Newly Diagnosed Glioblastoma Multiforme
NCT00165477 ·Status: COMPLETED ·Phase: PHASE2
-
Testing the Addition of the Chemotherapy Drug Lomustine (Gleostine) to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Methylated Glioblastoma
NCT05095376 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
A Study of Selinexor in Combination With Standard of Care Therapy for Newly Diagnosed or Recurrent Glioblastoma
NCT04421378 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
A Study of the Safety and Efficacy of Tarceva in Patients With First Relapse of Grade IV Glioma (Glioblastoma Multiforme)
NCT00337883 ·Status: COMPLETED ·Phase: PHASE2