A Randomized Trial of Recommendations for Exercise to Prevent Weight Regain

Summary

The investigators will conduct a randomized trial to evaluate the effectiveness of 3 levels of recommended exercise in initially overweight and obese sedentary men and women on the prevention of weight regain. Participants will complete a 3 mo. weight loss intervention of decreased energy intake (EI) and increased energy expenditure (100 minutes of physical activity per week). Participants achieving clinically significant weight loss (\> 5% of initial weight), will be randomly assigned to 12 mos. of exercise at levels of energy expenditure of exercise (EEEx) recommended by Health and Human Services (HHS), American College of Sports Medicine(ACSM), Institute of Medicine (IOM): 150, 225, or 300 minutes per week. Major outcome assessments will occur prior to weight loss (-3 mos.), at completion of weight loss (0 mos.), at the midpoint (6 mos.), and completion of weight maintenance (12 mos.).

Conditions

• Overweight
• Obesity
• Weight Loss

Interventions

BEHAVIORAL

150 Min/Week

Performs 150 min/wk of planned moderate intensity aerobic exercise.

BEHAVIORAL

225 Min/Week

Performs 225 min/wk of planned moderate intensity aerobic exercise.

BEHAVIORAL

300 Min/Week

Performs 300 min/wk of planned moderate intensity aerobic exercise.

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI)

  collaborator NIH

• University of Kansas

  lead OTHER

Principal Investigators

• Joseph Donnelly, EdD · University of Kansas

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

21 Years

Max Age

55 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2012-08-31

Primary Completion

2018-04-01

Completion

2018-12-31

Countries

• United States

Study Locations