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Optimalisation of Therapeutic Drug Monitoring (TDM) of Vancomycin in Patients With Central Venous Port Devices

NCT01661361 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 15

Last updated 2012-08-09

No results posted yet for this study

Summary

Recently, it was reported that when vancomycin levels are determined after port sampling, levels can be falsely increased potentially leading to wrong dose adjustments.

The investigators conducted an in vitro experiment using several central venous port devices, in which different flushing techniques were evaluated yielding residual vancomycin levels of less than 0.5 mg/L.

In this study, the investigators want to evaluate this flushing technique in vivo in 15 patients admitted with catheter-related infection and treated with systemic vancomycin and vancomycin antibiotic lock.

The purpose is to assess if correct flushing can avoid spurious vancomycin levels obtained via port sampling.

Conditions

  • Catheter-related Infection

Interventions

PROCEDURE

blood levels

Sponsors & Collaborators

  • Universitaire Ziekenhuizen KU Leuven

    lead OTHER

Principal Investigators

  • Isabel Spriet, PharmD PhD · Pharmacy Dpt, University Hospitals Leuven

  • Jan Verhaegen, MD PhD · Medical Diagnostic Sciences, University Hospitals Leuven

  • Hans Prenen, MD PhD · Digestive ONcology, University Hosptials Leuven

  • Willy Peetermans, MD PhD · Internal Medicine, University Hospitals Leuven

  • Ludo Willems, PharmD PhD · Pharmacy Dpt., University Hosptials Leuven

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-09-30
Primary Completion
2012-12-31
Completion
2012-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01661361 on ClinicalTrials.gov