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Complications and Failure of Centrally Inserted Central Catheters in Cardiac Surgical Patients

NCT07138690 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 480

Last updated 2025-09-03

No results posted yet for this study

Summary

Central venous catheters, or CVCs, are medical devices used to deliver medications and blood products directly into a patient's large veins. They are now an essential part of modern hospital care, but their use comes with potential complications.

Two of the most serious and well-studied complications are catheter-related bloodstream infections and catheter-related thrombosis (blood clots). These issues not only pose significant health risks to patients but also increase healthcare costs. Fortunately, the frequency of these complications has been reduced by following universally accepted prevention measures, such as:

Proper hand hygiene and skin disinfection before insertion

Using an ultrasound to guide the procedure

Applying best practices for ongoing catheter maintenance

Besides infections and blood clots, other complications like accidental displacement, lumen occlusion (blockage), or a suspected infection can lead to the early, or premature, removal of a CVC before the completion of the patient's treatment.

In patients undergoing cardiac surgery, CVCs are vital. They are used for general anesthesia, medication delivery, and continuous monitoring of a patient's heart and circulatory system. Because of this critical role, it's essential to constantly monitor the incidence of CVC-related complications in this patient population.

This single-center, retrospective study will investigate two primary objectives:

The frequency of catheter-related infections in adult patients undergoing cardiac surgery.

The frequency of premature catheter removals, or "catheter failures," in the same patient group.

The findings from this study will help improve the management of CVCs in cardiac surgery patients and reduce and prevent future complications.

Conditions

  • CRBSI - Catheter Related Bloodstream Infection
  • Central Venous Catheter
  • Catheter Failure
  • Central Venous Catheter Complications

Sponsors & Collaborators

  • Azienda Ospedaliero-Universitaria Careggi

    lead OTHER

Principal Investigators

  • Raffaele Mandarano, MD, MSc · Azienda Ospedaliero-Universitaria Careggi

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-06-01
Primary Completion
2023-12-31
Completion
2025-08-10

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07138690 on ClinicalTrials.gov